In 2007 she surpassed the rating of 2577 set by Susan Polgar to become the second-highest ranked female player in history. She became the second female player ever, after Judit Polgár, to exceed the 2600 Elo mark.

From 2002 through 2008, Humpy held the record as the youngest woman ever to become a grandmaster (not merely a Woman Grandmaster), which she achieved at the age of 15 years, 1 month, 27 days, beating Judit Polgár's previous mark by three months; however, this has since been surpassed by Hou Yifan.

In 2001 she won the World Junior Girls Chess Championship. In 2006 she participated in the Women's World Chess Championship, but was eliminated in the second round. In the Women's World Chess Championships 2008 and 2010 she made it to the semi-finals, but was beaten by Hou Yifan.

In 2006 She won 2 Gold Medals in Asian Games at Doha.In 2007 She won HSG international open in Netherlands and Kaupthing International open in Luxembourg. In 2008 she won 2 gold and 2 silver medals in Asian Indoor Games in Macau. In 2009 she tied for 1st-4th with Alexander Areshchenko, Magesh Panchanathan and Evgenij Miroshnichenko in the Mumbai Mayor Cup.

Humpy participated in the FIDE Women's Grand Prix 2009–2011 and finished in overall second position, in turn qualifying as challenger for Women's World Chess Championship 2011.

Interviews:

http://qatar2011.fide.com/interview-with-humpy-koneru.html

http://nalchik2010.fide.com/6th-round-press-conference.html